The serosa, also referred to as the serous membrane, is a vital component of the connective tissue that covers the outer surface of select organs in the human body. Its primary location is in the abdominal cavity, where it provides protection and support to organs like the stomach, liver, and intestines. The serosa is a thin, smooth and transparent layer that enables these organs to move smoothly against neighboring tissues. The membrane is composed of a layer of simple squamous epithelial cells, known as mesothelium, and is supported by a thin layer of connective tissue. The serosa secretes a small amount of serous fluid that acts as a lubricant, reducing friction between organs during digestion and other bodily processes.